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Dr Stefan Köstler

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Research interests

Evolution generates novel functions of proteins that drive development of organisms with increasing complexity. On the other hand there exists functional redundancy between related proteins. In the case of the SoxB1 family of transcription factors these shared functionalities are conserved over 800 million years of evolutionary time. In the group of Prof. Steve Russell I am aiming to decipher common and differential SoxB1 functions during early development of the Drosophila melanogaster CNS to obtain a better understanding of redundancy. I apply Drosophila genetics, genomic methods like ChIP-seq, and advanced microscopy methods. Furthermore, I established an online tool for the community curation of dynamic gene/protein interactions during fly eye development.

Publications

About us

The Cambridge Big Data Strategic Research Initiative brings together researchers from across the University to address challenges presented by our access to unprecedented volumes of data. Our research spans all six Schools of the University, from the underlying fundamentals in mathematics and computer science, to applications ranging from astronomy and bioinformatics, to medicine, social science and the humanities

In parallel, our research addresses important issues around law, ethics and economics, in order to apply Big Data to solve challenging problems for society.

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